SHORT COMMUNICATION: DAMAGE TO THE HISTOLOGICAL STRUCTURE OF MICE LIVER (Mus musculus) DUE TO EXCESSIVE CONSUMPTION OF SODIUM CHLORIDE

Authors

  • Rizqi Nur Ardiansyah Department of Conservation Biology Program
  • Arum Setiawan Department of Biology, Faculty of Mathematics & Natural Sciences, Sriwijaya University. Jalan Raya Palembang-Prabumulih km 32, Indralaya, Indonesia.
  • Yuanita Windusari Department of Biology, Faculty of Mathematics and Natural Sciences, Sriwijaya University. Palembang-Prabumulih Highway km 32, Indralaya, Indonesia

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DOI:

https://doi.org/10.24233/biov.8.1.2022.221

Keywords:

Liver cells , Mice (Mus musculus) , Sodium Chloride (NaCl)

Abstract

Salt or sodium chloride (NaCl) is used in everyday life mainly to give food taste. Salt is hepatotoxic, so excessive use of salt has an impact on the liver. The liver is one part of the organ that has an important role in the body's metabolism, especially in neutralizing toxins. The liver is composed of hepatocytes. There are 60% hepatocytes of the total cells in the liver. Hepatocytes are the main cells responsible for the central role of the liver in metabolism. Liver function becomes very vulnerable to damage because it continuously neutralizes toxins. Such damage can occur and affect the structure and function of the liver. This study was conducted to determine the structural abnormalities of hepatocytes that occur in the liver of mice (Mus musculus) due to excessive salt consumption. The method used in this study was a CRD (completely randomized design) method consisting of 1 control group and 3 treatment groups by sodium chloride (NaCl) with 6 replications. The parameter in this study was the level of hepatocyte damage in the liver of mice (Mus musculus). Hepatocyte damage that occurred was observed through histological preparations with Hematoxylin Eosin (HE) staining. The results of this study indicate that hepatocyte cell damage in the liver of mice (Mus musculus) increases due to continuous administration of excess sodium chloride (NaCl).

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References

Malhi H, Gores GJ. Cellular and molecular mechanisms of liver injury. Gastroenterology. 134(6):1641-1654. 2008.

Cotran, R., Kumar, V., & Collins, T. “Phatology Basic of Disease 6th”. Philadelphia; WB Saunders Co.P. 2007.

Rath KM, Maheshwari A, Bengtson P, Rousk J. Comparative Toxicities of Salts on Microbial Processes in Soil. Appl Environ Microbiol. 82(7):2012-2020. 2016.

Kurniawan, I. W. A. Y., Wiratmini, N. I., & Su-datri, N. W. “Histologi Hati Mencit (Mus Mus-culus L.) Yang Diberi Ekstrak Daun Lamtoro (Leucaena Leucocephala)”. Jurnal Simbiosis, 2(2), 226–235. 2014.

Tho N, Vromant N, Hung NT, Hens L. Organic pollution and salt intrusion in Cai Nuoc District, Ca Mau Province, Vietnam. Water Environ Res. 78(7):716-23. 2006.

Johnson GD, Lalancette C, Linnemann AK, Leduc F, Boissonneault G, Krawetz SA. The sperm nucleus: chromatin, RNA, and the nuclear matrix. Reproduction. 141(1): 21-36. 2011.

Celton-Morizur S, Desdouets C. Polyploidization of liver cells. Adv Exp Med Biol. 676:123-35. 2010.

Yaswir, R., & Ferawati, I. “Fisiologi dan Gangguan Keseimbangan Natrium, Kalium dan Klorida serta Pemeriksaan Laboratorium”. Jurnal Kesehatan Andalas, 1(2), 80–85. 2012.

Cahyaningrum, P., Windusari, Y. ., & Setiawan, A., Hippocampus cell disorders and neurosensory tests in mice (Mus musculus) due to induction of excess sodium chloride. Biovalentia: Biological Research Journal, 7(2): 97-100. 2021.

Published

02-02-2022

How to Cite
Write scientific names with Italic fonts:

Ardiansyah, R. N., Setiawan, A. ., & Windusari, Y. . (2022). SHORT COMMUNICATION: DAMAGE TO THE HISTOLOGICAL STRUCTURE OF MICE LIVER (Mus musculus) DUE TO EXCESSIVE CONSUMPTION OF SODIUM CHLORIDE. BIOVALENTIA: Biological Research Journal, 8(1), 43–45. https://doi.org/10.24233/biov.8.1.2022.221

Issue

Section

Vol 8, No 1 (2022): May 2022

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