THE CAPABILITY OF SEDATIVE EFFECT FROM CELERY (Apium graveolens L.) FRACTION TO MALE MICE
DOI:
https://doi.org/10.24233/BIOV.4.2.2018.111Keywords:
Sedation , traction , test , fireplace , Apium graveolensAbstract
Celery fraction research (Apium graveolens L.) was carried out to determine the ability of the sedation effect of celery fraction compared to celery extracts which have been known to have the ability to effect the previous sedation. This study aims to find out which fraction has the best sedation effect. This study was an experimental study with a Completely Randomized Design (CRD) consisting of 5 treatments and 5 replications. Test animals divided into 5 treatment groups namely negative control group (CMC Na 1%), celery extract group 200mg /kg and 3 treatment groups n-hexane fraction, ethyl acetate, and methanol water fraction with a dose of 200 mg /kg . The sedation effect test was carried out using the Traction Test and Fireplace Testmethods. Quantitative data observed were the length of time the mice fell and the length of time the mice went out of the heated tube/glass. The results of the analysis showed that the celery fraction had a better sedation effect than the extract, and the methanol water fraction 200 mg/kg was the most effective fraction in causing sedation effects.
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References
S. Ningsih and N. Rahma, “Kemampuan Efek Sedasi Infusa Umbi Rumput Teki (Cyperus rotundus L ) pada Mencit Jantan Ras Swiss,” Indones. J. Med. Sci., vol. 1, no. 1, pp. 1–5, 2014.
Bowman WC, Rand J. 1985. Humoral Mechanism in The Central Nervous System. Textbook of Pharmacology. 2nd edition. Oxford London: Blackwell Scientific Publications.
Puradisastra, Sugiarto, and Iwan Budiman. 2007. “Efek Hipnotik Biji Seledri ( Apium Graveolens L .) Pada Mencit Jantan Galur Ddy Dan Pengaruhnya Terhadap Waktu Reaksi Sederhana ( WRS ) Pada Manusia.” JKM Vol 7 No.1: 62–70.
Tan Hoay Tjay, Kirana Rahardja. 2002. Obat-Obat Penting : Khasiat, Penggunaan dan Efek-efek sampingnya, Edisi kelima. Jakarta: PT Elex Media Komputindo. p. 358.
Gunawan SG, Settiabudy R, Nafrialdi, Elysabeth, editor. 2007. Farmakologi dan Terapi. Edisi 5. Gaya Baru: Jakarta.
Aziz, Abdul, Imran Ahmad Khan, Musaddique Hussain, and Muhammad Asif Raza. 2014. “Pharmacological Evaluation of Sedative Activity of Methanolic Extract of Thuja Occidentalis in Mice .” 2(1): 202–10.
Arifin Helmi, Meydiza Fahrefi, Surya Dharma. 2013. “Pengaruh Fraksi Air Herba Seledri ( Apium Graveolens L.) Terhadap Kadar Kolesterol Total Mencit Putih Jantan Hiperkolesterol.” Prosiding Seminar Nasional Perkembangan Terkini Sains Farmasi Dan Klinik III 2013, 293–304.
Sudarsono. 1996. Tumbuhan Obat, Hasil Penelitian, Sifat-sifat dan Penggunaan. Pusat Penelitian Obat Tradisional. UGM. Yogyakarta.
Majidah, Dewi, Dwi Warna Aju Fatmawati, Achmad Gunadi, 2014. “Daya Antibakteri Ekstrak Daun Seledri ( Apium Graveolens L .) Terhadap Pertumbuhan Streptococcus Mutans Sebagai Alternatif Obat Kumur” Artikel Ilmiah Hasil Penelitian Mahasiswa.
Fazal, Syed Sufiyan, Mohammad Mansoor Ansari, Rajeev K Singla, and Salim Khan. 2012. “Isolation of 3-N-Butyl Phthalide & Sedanenolide from Apium” 2 (3): 258–61.
Marlinda, Mira, Meiske S Sangi, and Audy D Wuntu. 2012. “Analisis Senyawa Metabolit Sekunder Dan Uji Toksisitas Ekstrak Etanol Biji Buah Alpukat (Persea Americana Mill .).” Jurnal MIPA Unsrat Online 1 (1): 24–28.
Simaremare, Eva Susanty. 2014. "Skrining Fitokimia Ekstrak Etanol Daun Gatal (Laportea decumana (Roxb.) Weed)." Pharmacy, Vol.11 No.01: 98-107.
Alnamer, Rachad, Katim Alaoui, El Houcine Bouidida, Abdelaziz Benjouad, and Yahia Cherrah. 2012. “Sedative and Hypnotic Activities of the Methanolic and Aqueous Extracts of Lavandula Officinalis from Morocco.” Advances in Pharmacological Sciences 2012.
Sari, Dwi Puspita, Lucia Maria Santoso, and Kodri Madang.
“Pengaruh Ekstrak Daun Pepaya (Carica Papaya L.) Terhadap Efek Sedasi Pada Mencit (Mus Musculus L.) Dan Sumbangannya Pada Pembelajaran Biologi Sma.” Jurnal Pembelajaran Biologi, Volume 3, Nomor 2, no. 2012: 183–89.
Purnomo, Loka, Lusiana Darsono, Slamet Santosa, Dosen Bagian, Farmakologi Fakultas, and Kedokteran Uk. 2004. “Sebagai Obat Hipnotik Sedatif.” JKM 3 No. 2: 96–110.
Erwin, Iswandi, and Donni Indra Kusuma. 2012. “Inhibitor Asetilkolinesterase Untuk Menghilangkan Ffek Relaksan Otot Non-Depolarisasi.” Cermin Dunia Kedokteran 39 (5): 333–39.
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