HIPPOCAMPUS CELL DISORDERS AND NEUROSENSORY TESTS IN MICE (Mus musculus) DUE TO INDUCTION OF EXCESS SODIUM CHLORIDE

Authors

  • Putri Cahyaningrum Pascasarjana UNSRI
  • Yuanita Windusari Department of Biology, Faculty of Mathematics & Natural Sciences, Sriwijaya University. Jalan Raya Palembang-Prabumulih km 32, Indralaya, Indonesia
  • Arum Setiawan Department of Biology, Faculty of Mathematics & Natural Sciences, Sriwijaya University. Jalan Raya Palembang-Prabumulih km 32, Indralaya, Indonesia

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DOI:

https://doi.org/10.24233/biov.7.2.2021.222

Keywords:

sodium chloride , hippocampus , mice (Mus musculus)

Abstract

Salt or sodium chloride (NaCl) is an additive to give food a salty taste. The use of salt in everyday life is difficult to avoid. Salt has both good and bad effects on the body. The electrolyte content of salt can help launch metabolism in the body, whereas if the body contains too much salt it will cause heart attacks and hypertension. The dose of salt consumption that has been set by the government is 5g/day. This study was conducted to examine the effect of consuming excessive sodium chloride (NaCl) on the ability to smell and to what extent it damages cells in the hippocampus of mice (Mus musculus). The method of this study was CRD (completely randomized design) with 6 replications, 1 group control and 3 repetitions induced by sodium chloride (NaCl) is 260mg/gBB (P1), 520mg/gBB (P2), and 780mg/gBB (P3). The parameters of this study are neurosensory coordination in the form of olfactory response of mice (Mus musculus) to ammonia and cell disruption in the hippocampus (DG & CA) which were observed by histological preparations of Hematoxylin eosin (HE) staining. The results of this study indicate the presence of olfactory disorders in mice (Mus musculus) and cell death in the hippocampus also increased due to excessive sodium chloride (NaCl) induction. The more salt is consumed in daily life, it will disrupt the cells in the hippocampus.

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References

Darmanto W., E. Prihiyantoro dan R. Harmonis, “Induksi 2-Methoxyethanol pada masa prenatal sebagai penyebab kelainan otak pada mencit” Ber. Pen. Hay., 10: 1–5. 2004.

Ge, Q. et al., "High salt diet impairs memory-related synaptic plasticity via increased oxidative stress and suppressed synaptic protein expres-sion", Molecular Nutrition and Food Research, 61(10), pp. 1–11. doi: 10.1002/mnfr.201700134. 2017.

Guo, C. P. et al., "High salt induced hypertension leads to cognitive defect", Oncotarget, 8(56), pp. 95780–95790. 2017.doi: 10.18632/oncotarget.21326.

Hayman, L. A. et al., "Pictorial Essay The Hippo-campus : Normal Anatomy and Pathology Dentate gyrus", American Journal of Roentgenology, 171(October), pp. 1139–1146. 1998.

Kim, E. J., Pellman, B. and Kim, J. J, "Stress ef-fects on the hippocampus: A critical review’, Learning and Memory", 22(9), pp. 411–416. 2015. doi: 10.1101/lm.037291.114.

Matzel, L. D. et al., "Individual differences in the expression of a “general” learning ability in mice’, Journal of Neuroscience", 23(16), pp. 6423–6433.2003. doi: 10.1523/jneurosci.23-16-06423.

Nelson, B.K., Brighwell, W.S., Burg, J.R. & Mas-sari, V.J, "Behavioral and neurochemical altera-tions in offspring of rat after maternal or paternal inhalation exposure to the indutrial solvent 2-methoxyethanol. pharmacol", Biochem. Behav., 20(2):269-270. 1984.

Noeradiana, Aureliya Hutagaol, & Yafrinal Sire-gar, "Pemberian Vitamin E Terhadap Eritrosit Pada Mencit (Mus musculus) yang Dipapari Tuak", STIKES Imelda Medan. 3 (2). 2017.

PPRI, "Peraturan Pemerintah Republik Indonesia no.722/Menkes/per/IX/ 88, tentang Bahan Tam-bahan Pangan", Jakarta. 2019.

Rinaldi, "A.‘The scent of life. The exquisite com-plexity of the sense of smell in animals and hu-mans", EMBO Reports, 8(7), pp. 629–633. 2007.doi: 10.1038/sj.embor.7401029.

Setiawan, A. et al., "Koordinasi Neuromuskular Mencit (Mus musculus) Pascasapih Setelah In-jeksi Ochratoksin A Secara Intrasisternal", UNSRI: Palembang. 2020.

Tri, W. Marti, H. Shanti, L, "Pengaruh Ekstrak Daun Sambiloto (Andrographis Paniculata) Ter-hadap Struktur Mikroanatomi Hepar Dan Kadar Glutamat Piruvat Transaminase Serum Mencit (Mus Musculus) Yang Terpapar Diazinon," Jurnal Bioteknologi 4 (2): 53-58 (0216-6887). FMIPA Universitas Sebelas Maret (UNS). Surakarta. 2006.

Yaswir, R. and Ferawati, I, "Fisiologi dan Gangguan Keseimbangan Natrium, Kalium dan Klorida serta Pemeriksaan Laboratorium", Jurnal Kesehatan Andalas, 1(2), pp. 80–85. 2012. doi: 10.25077/jka.v1i2.48.

Published

07-11-2021

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Cahyaningrum, P., Windusari, Y. ., & Setiawan, A. . (2021). HIPPOCAMPUS CELL DISORDERS AND NEUROSENSORY TESTS IN MICE (Mus musculus) DUE TO INDUCTION OF EXCESS SODIUM CHLORIDE. BIOVALENTIA: Biological Research Journal, 7(2), 97–100. https://doi.org/10.24233/biov.7.2.2021.222

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Section

Vol 7, No 2 (2021): Nov 2021

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